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September 10, 2025Journal for ImmunoTherapy of CancerOpen Access

Integrated system for screening tumor-specific TCRs, epitopes, and HLA subtypes using single-cell sequencing data

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Authors

XWXianyao WangCentral South UniversityXSXuelian SongYLYi W. LiChinese Academy of Medical Sciences & Peking Union Medical College

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Implication

Observational analysis identified tumor-specific TCRs in cervical cancer patients, suggesting a novel approach for TCR-T immunotherapy.

Key Points

  • The developed system rapidly clones and constructs TCR libraries in 2 days, enhancing efficiency and reducing costs.
  • High sensitivity was demonstrated for screening functional TCRs using Jurkat reporter cells, validating the method's effectiveness.
  • The approach successfully isolated an HPV-specific TCR that recognized a specific peptide presented by HLA-B*15:18.
  • This integrated system facilitates personalized screening and may advance TCR-T immunotherapy, addressing tumor heterogeneity.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d64792284https://doi.org/10.1136/jitc-2025-012029
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