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September 10, 2025Stem Cell Reviews and ReportsOpen Access

Umbilical Cord Blood Endothelial Progenitor Cells Modulate Neurovascular Unit Damage in a Neonatal Rat Model of Hypoxia Ischemia

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Authors

TPTayla R. PennyYPYen PhamASAmy E. Sutherland

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Overview

Investigation reveals that endothelial progenitor cells reduce blood brain barrier injury in neonatal hypoxia ischemia, suggesting potential therapeutic avenues.

Key Points

  • EPC treatment significantly reduced neuropathology and improved blood brain barrier integrity.
  • At 7 days post-hypoxia ischemia, tissue loss was significantly lower in EPC-treated rats compared to controls.
  • HI induced clear BBB dysfunction, with reduced GLUT1 and claudin-5 expression, which was improved by EPC administration.
  • These findings highlight the potential of EPCs as a neuroprotective strategy against neonatal hypoxia ischemia.

Cite This Study

Penny et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d64791d1ahttps://doi.org/10.1007/s12015-025-10939-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human Umbilical Cord–Derived Cells Therapy for Hypoxic‐Ischemic Encephalopathy: A Systematic Review and Meta‐Analysis of Animal Models2025
  2. 2Cord blood-derived cell therapy for preterm brain injury2025
  3. 3Brainstem microglial cell morphology in neonatal rats with necrotizing enterocolitis and the effects of prenatal heparin-binding epidermal growth factor-like growth factor2025 · 1 citations
  4. 4Single‐Cell Transcriptomic Profiling of Brain Cells in Newborn Rats Following Hypoxic Ischemic Encephalopathy2025
  5. 5Intraperitoneal rescue stem cell therapy in experimental NEC mitigates intestinal, pulmonary, and neuroinflammatory injury in mice2025