Combination therapy with ultrasound and microbubbles improves renal function and fibrosis in chronic kidney disease models, suggesting novel treatment avenues.
Key Points
Combination of ultrasound and microbubbles significantly improved renal function in CKD rats.
Treatment with MCC950 and ultrasound reduced kidney damage markers, particularly in serum creatinine and blood urea nitrogen.
Ultrasound combined with microbubbles enhanced the inhibitory effects of MCC950 on NLRP3 inflammasome activation in renal tissues.
Results indicate potential for combining ultrasound therapy with inflammasome inhibitors for protecting against kidney fibrosis.