Integrated proteomic and metabolomic profiling identifies distinct molecular signatures and metabolic pathways associated with obesity and potential targets for anti-obesity therapies
This integrative analysis identifies key metabolic pathways and molecular targets related to obesity, suggesting novel therapeutic strategies.
Key Points
Key alterations in metabolic pathways were identified, emphasizing distinct signatures linked to obesity and metabolic dysfunction.
Proteomic profiling revealed 135 differentially expressed proteins, with notable upregulation of PHACTR2 and PLIN2 in obese individuals.
Metabolomic analysis revealed 191 differential metabolites, indicating significant correlations with BMI and obesity-related metabolic processes.
This integrative approach underscores the importance of multi-omics in understanding the molecular influences of bariatric surgery on adipose remodeling.