The incidence, risk factors, and survival of acute myeloid leukemia secondary to chronic myelomonocytic leukemia: a population-based study

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Population-based analysis shows high incidence and poor survival of s-AML in CMML patients, indicating risk factors.

The study found that acute myeloid leukemia (s-AML) develops in about 10.8% of chronic myelomonocytic leukemia patients within the first year.
Younger patients and those exposed to chemotherapy at CMML diagnosis were identified as significant risk factors for s-AML development.
Post-progression survival (PPS) for s-AML was low, with a median survival of just 4 months, highlighting the disease's aggressive nature.
Factors such as marital status, income, and race/ethnicity also played a critical role in the overall survival of patients with CMML.

Zheng et al. (2025) studied this question.

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View Full Paper

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Authors

Population-based analysis shows high incidence and poor survival of s-AML in CMML patients, indicating risk factors.

The study found that acute myeloid leukemia (s-AML) develops in about 10.8% of chronic myelomonocytic leukemia patients within the first year.
Younger patients and those exposed to chemotherapy at CMML diagnosis were identified as significant risk factors for s-AML development.
Post-progression survival (PPS) for s-AML was low, with a median survival of just 4 months, highlighting the disease's aggressive nature.
Factors such as marital status, income, and race/ethnicity also played a critical role in the overall survival of patients with CMML.

Zheng et al. (2025) studied this question.

View Full Paper

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