In Silico Identification of Phenylacetaldehyde's Impact on Downregulating Malignancy-Associated Genes: A Promising Therapeutic Approach Against Colorectal Cancer

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Analysis reveals phenylacetaldehyde downregulates oncogenes in colorectal cancer, suggesting potential therapeutic roles.

Phenylacetaldehyde significantly reduces the expression of 54 malignancy-associated genes in colorectal cancer.
Key hub genes identified include MCM2, MCM4, and PCNA, which are linked to tumor proliferation.
Integration of clinical data helps identify biomarkers like IFI30 related to poor prognosis in cancer patients.
The study highlights phenylacetaldehyde's potential as a therapeutic candidate, needing further validation.

Rohani et al. (2025) studied this question.

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