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September 10, 2025Gastroenterology InsightsOpen Access

Targeting Advanced Pancreatic Ductal Adenocarcinoma: A Practical Overview

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Authors

CCChiara CitterioSVStefano VecchiaPMPatrizia Mordenti

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Overview

This narrative review highlights actionable genomic alterations in pancreatic ductal adenocarcinoma, emphasizing molecular profiling and targeted therapies.

Key Points

  • Targeted therapies have shown modest clinical impact in pancreatic ductal adenocarcinoma with actionable genomic alterations.
  • Molecular profiling reveals critical mutations like KRAS G12C and BRCA1/2, but only a minority of patients qualify for targeted treatments.
  • A narrative review approach was employed, utilizing databases such as PubMed and Scopus to gather the latest data and guidelines.
  • Systematic molecular profiling is vital for guiding therapy strategies and aligning clinical management with precision oncology.

Cite This Study

Citterio et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d647904fehttps://doi.org/10.3390/gastroent16030026
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