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September 10, 2025DiagnosticsOpen Access

Clonal Hematopoiesis of Intermediate Potential in Atrial Fibrillation: A Critical View of Current Knowledge as a Springboard for Future Research

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Authors

ECElena ChatzikalilDADimitrios AsvestasSTStylianos Tzeis

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Overview

This review explores the impact of CHIP mutations on atrial fibrillation severity and cardiovascular risk, highlighting potential mechanisms.

Key Points

  • Clonal hematopoiesis of intermediate potential is associated with a two-fold increase in cardiovascular risk, emphasizing its clinical importance.
  • Patients with atrial fibrillation show a higher incidence of CHIP mutations like TET2 and DNMT3A compared to healthy controls.
  • The presence of TET2 and ASXL1 mutations is correlated with increased interleukin-6 levels, which are linked to cardiac remodeling.
  • Research aims to clarify how CHIP mutations contribute to atrial fibrillation severity and the potential for targeted interventions.

Cite This Study

Chatzikalil et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d6478ffe5https://doi.org/10.3390/diagnostics15151915
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