September 10, 2025Food & Function

Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

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Probiotics significantly alleviate liver injury from alcohol exposure, restoring gut health and function.
The treatment notably enhanced the intestinal barrier integrity, and regulated AMPK and TLR4/NF-κB pathways.
Alcoholic liver disease (ALD) increases vulnerability to liver damage, impacting global public health challenges.
This study highlights potential probiotic interventions for managing alcohol-induced liver complications.

Implication

Animal study shows reduced liver injury and improved gut microbiota in mice, suggesting benefits of probiotics on alcoholic liver disease.

Abstract

Alcohol consumption poses a major global public health challenge, with excessive drinkers showing heightened susceptibility to alcoholic liver disease (ALD) – a condition with complex pathogenesis.

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Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d6478fd40 https://doi.org/10.1039/d5fo00915d

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Implication

Animal study shows reduced liver injury and improved gut microbiota in mice, suggesting benefits of probiotics on alcoholic liver disease.

Abstract

Alcohol consumption poses a major global public health challenge, with excessive drinkers showing heightened susceptibility to alcoholic liver disease (ALD) – a condition with complex pathogenesis.

Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

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