Genome-Wide Analysis and Longitudinal Study of Klebsiella pneumoniae in Portugal: Tracing the Evolution and Spread of Carbapenem Resistance

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Longitudinal study examines the spread and evolutionary history of carbapenem-resistant Klebsiella pneumoniae, highlighting surveillance need.

Nineteen genomic clusters harboring carbapenemases were identified, with the blaKPC-3 gene showing significant prevalence.
Over a 40-year period, ST15 was the most established sequence type in Portugal, highlighting a shift to ST147 and ST13 clones.
Bayesian evolutionary analysis was conducted on prevalent sequence types to estimate divergence times and track evolution.
This work underscores the need for cross-border surveillance to monitor CRKP strains and inform risk assessments.

Elias et al. (2025) studied this question.

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Longitudinal study examines the spread and evolutionary history of carbapenem-resistant Klebsiella pneumoniae, highlighting surveillance need.