September 10, 2025NeuroImage ClinicalOpen Access

Contralateral prefrontal and network engagement during left DLPFC 10 Hz rTMS: an interleaved TMS-fMRI study in healthy adults

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10 Hz rTMS over the left DLPFC induced BOLD responses in various brain regions, highlighting distinct neural mechanisms.
Notable lateralization to the contralateral right DLPFC was observed in response to 10 Hz rTMS stimulation.
Dose-response effects between 40% and 80% resting motor threshold were specifically noted in the hippocampus.
Interleaved TMS-fMRI serves as a valuable approach for assessing the impact of different rTMS protocols on brain engagement.

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Interleaved TMS-fMRI reveals BOLD activity changes following left DLPFC stimulation, indicating robust neural mechanisms.

Hattem et al. (2025) studied this question.

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