CAR-Macrophage Cell Therapy: A New Era of Hope for Pancreatic Cancer

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CAR-macrophage therapy enhances anti-tumor responses in pancreatic cancer, indicating a breakthrough in immunotherapy.
Preclinical data show CAR-Ms improve antigen presentation and recruit cytotoxic T cells, amplifying immune responses.
Innovative CAR-M engineering strategies strengthen therapeutic potential, showcasing dual-targeting and CRISPR modifications.
Addressing CAR-M persistence and manufacturing scalability is crucial for successful implementation in pancreatic cancer therapy.

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Review highlights advances in CAR-macrophage therapy for pancreatic ductal adenocarcinoma, suggesting a new strategy against treatment resistance.

Wei et al. (2025) studied this question.

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Review highlights advances in CAR-macrophage therapy for pancreatic ductal adenocarcinoma, suggesting a new strategy against treatment resistance.