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September 10, 2025Drug DeliveryOpen Access

Enhancing targeted delivery and efficacy of PEGylated liposomal doxorubicin with liposomal minoxidil: comprehensive in silico, in vitro, and in vivo tumor model studies

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Authors

VMVahideh MohammadzadehLALeila ArabiSHSeyedeh Maryam Hosseinikhah

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Overview

Research reveals that minoxidil-loaded liposomes enhance drug delivery in CRC and PCa cancers, improving therapeutic outcomes.

Key Points

  • Lip-MXD formulation significantly improved drug delivery and reduced tumor volume in mouse models of colorectal cancer.
  • A single dose of PLD following Lip-MXD pretreatment resulted in a 60% survival rate in CRC models over a 14-day evaluation period.
  • Lip-MXD demonstrated vasodilatory effects that improved nanoparticle penetration in fibrotic tumors, indicating its potential for tumor treatment.
  • Molecular dynamics simulations confirmed the effectiveness of Lip-MXD in modulating CLDN-1 expression and enhancing drug efficacy.

Cite This Study

Mohammadzadeh et al. (2025) studied this question.

synapsesocial.com/papers/68c23dc5b210217d6478f5e8https://doi.org/10.1080/10717544.2025.2536802
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