Longitudinal analysis reveals depressive symptoms impact cognitive decline in men but not women with MCI, suggesting a need for tailored prevention strategies.
Key Points
Increasing depressive symptoms in men were linked to steeper rates of cognitive decline and higher dementia risk.
Men showed an increased risk of dementia with higher depressive symptoms, while women did not exhibit these associations.
Analysis of various cognitive domains reinforced the primary findings in men regarding depressive symptoms and cognitive decline.
The results imply that preventive strategies for dementia should consider sex-specific effects of depression.