September 10, 2025JMIRx MedOpen Access

Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study

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Discussion

Retrospective cohort study shows a 18.7% incidence of cardiovascular complications in pediatric cancer survivors, highlighting key risk factors.

The cumulative incidence of cardiovascular complications was 18.7% by 30 years postdiagnosis.
Significant risk factors include anthracycline exposure and chest radiation, increasing risk substantially.
Cox proportional hazards models were used to identify risk factors and develop a prediction model.
Findings indicate the necessity for lifelong cardiovascular monitoring in childhood cancer survivors.

Mansoor et al. (2025) studied this question.

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Retrospective cohort study shows a 18.7% incidence of cardiovascular complications in pediatric cancer survivors, highlighting key risk factors.