September 10, 2025MedicineOpen Access

Diagnostic efficacy of serum Krebs von den Lungen-6 for dermatomyositis/polymyositis-associated interstitial lung diseases: A systematic review and meta-analysis

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Serum KL-6 shows a high sensitivity of 0.82 and specificity of 0.90 for diagnosing DM/PM-ILD.
Analysis of 334 studies included 9, revealing KL-6 levels in DM/PM patients with ILD to be significantly higher.
The combined summary receiver operating characteristic curve for KL-6 reached 0.91, suggesting strong diagnostic accuracy.
Significant correlation exists between KL-6 levels and various pulmonary function parameters, highlighting its importance.

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Systematic review demonstrates KL-6's high sensitivity and specificity for diagnosing DM/PM-ILD, indicating its clinical potential.

Li et al. (2025) studied this question.

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