September 10, 2025

Mechanism by which mechanical stimulation regulates chondrocyte apoptosis and matrix metabolism via primary cilia to delay osteoarthritis progression.

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Authors

HLHuixian LingCentral South University SWSha WuSecond Affiliated Hospital of Guangzhou Medical University ZLZiyu LuoHunan University

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Implication

Observational analysis shows mechanical stimulation reduces chondrocyte apoptosis in osteoarthritis, suggesting potential therapeutic targets via primary cilia.

Key Points

Mechanical stimulation significantly delays osteoarthritis progression by reducing chondrocyte apoptosis.
Treadmill exercise improved balance ability and reduced apoptotic cell rates in wild-type OA mice but not in IFT88-deficient mice.
Cyclic tensile strain inhibited IL-1β-induced ECM degradation and chondrocyte apoptosis in primary cells.
Primary cilia play a crucial role in mediating the effects of mechanical stimulation on osteoarthritis.

Cite This Study

Ling et al. (2025) studied this question.

synapsesocial.com/papers/68c23d81b210217d6478df7a https://doi.org/10.11817/j.issn.1672-7347.2025.250187

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Implication

Observational analysis shows mechanical stimulation reduces chondrocyte apoptosis in osteoarthritis, suggesting potential therapeutic targets via primary cilia.