September 10, 2025

Effects of Lifetime Exposure to Sports-Related Head Impacts on Brain Injury and Inflammatory Blood Biomarkers Among Former Middle-Aged Athletes.

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Cross-sectional study reveals no differences in brain injury markers among former contact athletes, indicating chronic inflammatory responses.

No significant differences in brain injury biomarkers between former contact and noncontact athletes were found.
Age correlated with increased neurofilament light levels in contact athletes, while concussion history linked to higher UCH-L1 and tau levels.
Contact athletes had elevated systemic inflammatory markers, suggesting chronic inflammation due to previous head impacts.
Findings highlight the need for monitoring former athletes for potential neurodegenerative risks associated with sports-related head impacts.

Recht et al. (2025) studied this question.

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Cross-sectional study reveals no differences in brain injury markers among former contact athletes, indicating chronic inflammatory responses.