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September 10, 2025Open Access

What needs to be standardized for reliable, reproducible, and robust tractography?

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Authors

JLJon Haitz LegarretaBrigham and Women's HospitalSSSimona SchiaviUniversity of VeronaWTWei TangUnion Hospital

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Implication

This article uncovers the issues in tractography standardization, highlighting its impact on reproducibility in brain connectivity studies.

Key Points

  • Establishing standard protocols is essential for reliable and reproducible tractography results.
  • Inconsistencies in data acquisition and spatial referencing hinder the robustness of tractography findings.
  • The variability in methodologies complicates the development of effective automated quality control measures.
  • Harmonized approaches will facilitate larger-scale and more reliable analyses across diverse populations.

Cite This Study

Legarreta et al. (2025) studied this question.

synapsesocial.com/papers/68c23d81b210217d6478de87https://doi.org/10.31234/osf.io/qgkzu_v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Consensus tractography: decreasing algorithm dependency to improve fiber reconstructions2025
  2. 2Cross-species Standardised Cortico-Subcortical Tractography2025
  3. 3Cross-species standardised cortico-subcortical tractography2025
  4. 4Atlas-based templates vs. subject-specific tractography: resolving the debate2025 · 4 citations
  5. 5Precision Cortex Tractography for the Developing Brain2025