Study of Low-Risk GTN Patients Resistant to First-Line Chemotherapy with MTX in a Tertiary Hospital Center

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Retrospective analysis of chemotherapy resistance in low-risk GTN patients, highlighting hCG levels and treatment response.

Resistance to first-line chemotherapy occurred in 48.6% of patients using weekly methotrexate.
A complete response was achieved in 72.6% of low-risk GTN patients with initial treatment.
Higher pretreatment serum hCG levels and FIGO scores correlated with resistance to first-line chemotherapy.
All low-risk GTN patients had a 100% complete response rate after subsequent treatments.

Farazestanian et al. (2025) studied this question.

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