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September 10, 2025Frontiers in Behavioral NeuroscienceOpen Access

Sex differences in outcomes of first episode psychosis: results from an early intervention service

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Authors

IDIlaria DomenicanoAOAlice OnofrioMCMartina Citton

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Overview

Longitudinal cohort study reveals sex-based differences in clinical recovery rates for first episode psychosis, highlighting implications for treatment.

Key Points

  • Men showed significantly lower clinical severity than women at 6 and 12 months, indicating a faster clinical improvement.
  • At admission, men had higher rates of cannabis use (56.6% vs. 22.2%), tobacco (62% vs. 28.9%), and alcohol misuse (51.2% vs. 15.5%).
  • By 24 months, a greater percentage of men (26.3%) were NEET compared to women (8%), implying divergent recovery trajectories.
  • The study emphasizes the importance of identifying sex-specific outcomes for better clinical trajectories and prognosis.

Cite This Study

Domenicano et al. (2025) studied this question.

synapsesocial.com/papers/68c23d81b210217d6478ddefhttps://doi.org/10.3389/fnbeh.2025.1642460
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gender differences in neurocognitive impairment among first-episode, drug-naïve schizophrenia patients: a cross-sectional study2025
  2. 2Gender differences in clinical presentation and therapeutic response in schizophrenia2025
  3. 3Sex differences and age of onset in well-being and recovery in people with psychotic disorders. A PHAMOUS study2025
  4. 4Long-Term Outcomes in First-Episode Psychosis: Insights from a 20-Year Cohort Study to Inform Recovery-Oriented Care Models2025
  5. 5Socio-demographic characteristics of a First-Episode Psychosis Programme2025