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September 10, 2025Journal of Medical Virology

Epidemiology and Genetic Surveillance of Human Hepatitis E Virus Infections in Shandong Province, Eastern China, 2019–2023

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BYBingyu YanJLJingjing LvYFYi Feng

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Overview

Integration of enhanced hepatitis E surveillance reveals genetic diversity and clinical correlations of HEV-4 in Shandong, suggesting the need for ongoing monitoring.

Key Points

  • In total, 5826 hepatitis E cases were reported from 2019 to 2023, predominantly affecting males aged over 40.
  • The study identified the HEV-4d strain as dominant, comprising 84% of cases, alongside minor strains and imported types.
  • Molecular profiling showed high nucleotide similarity between human HEV-4d strains and indigenous strains from livestock in Shandong.
  • Ongoing molecular surveillance is crucial to understand HEV's transmission dynamics under the One Health framework.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478d656https://doi.org/10.1002/jmv.70595
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Also Consider

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  1. 1Molecular epidemiological investigation of swine hepatitis e virus (sHEV) in Guangdong Province, China: prevalence, genotypic characteristics, and zoonotic risk2026
  2. 2Hepatitis E Virus Detection in Swine Livers and Feces in Heilongjiang, Northeastern China2025
  3. 3Genotype Distribution and Migration Patterns of Hepatitis C Virus in Shandong Province, China: Molecular Epidemiology and Phylogenetic Study2025
  4. 4Clinical Characteristics and Epidemiological Features of Hepatitis E Virus Infection Among People Living with HIV in Shanghai, China2025
  5. 5Epidemiological trends of hepatitis in mainland China: 2004–20192025