The influence of the inducer of the transcription factor Nrf2 on metabolic parameters in rat tissues upon injection of hemin

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Observational analysis revealed nrf2 induction influences oxidative stress markers in rat tissues, suggesting therapeutic potential.

Hemin administration increased TBARS in the heart and decreased thiols in organs, activating catalase.
Dimethyl fumarate reduced TBARS in the heart and increased thiol groups and arginase activity in the kidneys and liver.
Combined hemin and DMF administration raised TBARS levels in kidneys and heart while enhancing urea and enzymatic activity.
These findings imply that nrf2 activation plays a critical role in responses to oxidative stress.

Охріменко et al. (2025) studied this question.

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