September 10, 2025Connective Tissue ResearchOpen Access

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis

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Review highlights the role of omics technologies in understanding osteoarthritis, indicating potential for personalized treatments.

Omics technologies revealed critical molecular pathways in osteoarthritis, facilitating the identification of endotypes.
Multi-omics integration demonstrated interactions among inflammatory, metabolic, and degradative processes affecting osteoarthritis.
Challenges like data complexity and lack of standardized frameworks are hindering the rapid progress in osteoarthritis therapies.
Future research leveraging artificial intelligence and spatial omics may enhance the development of personalized therapies for osteoarthritis.

Welsing et al. (2025) studied this question.

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