September 10, 2025BiomedicinesOpen Access

Association Between the Renin–Angiotensin System and Ibrutinib-Related Cardiovascular Adverse Events: A Translational Cohort Study

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Authors

JFJonaz FontInserm AHAmir HodžićInserm ASAngélique Da SilvaCentre Hospitalier Universitaire de Caen Normandie

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Implication

Cohort study links renin-angiotensin system to increased cardiovascular adverse events in patients treated with ibrutinib, suggesting potential predictors.

Key Points

Elevated baseline plasma renin levels correlated with a higher occurrence of cardiovascular adverse events.
Patients with high renin experienced a 57% occurrence of cardiovascular adverse events compared to 11% with lower levels.
The study used a prospective, single-center cohort approach to analyze predictors of cardiovascular events related to ibrutinib.
Findings indicate the renin-angiotensin-aldosterone system's potential role in ibrutinib-related cardiovascular toxicity.

Cite This Study

Font et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478cf16 https://doi.org/10.3390/biomedicines13092184

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Implication

Cohort study links renin-angiotensin system to increased cardiovascular adverse events in patients treated with ibrutinib, suggesting potential predictors.

Association Between the Renin–Angiotensin System and Ibrutinib-Related Cardiovascular Adverse Events: A Translational Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Association Between the Renin–Angiotensin System and Ibrutinib-Related Cardiovascular Adverse Events: A Translational Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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