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September 10, 2025Drug Development Research

Triazole‐Pyrimidine Hybrids as EGFR Inhibitors via Synthesis, In Silico, In Vitro, and In Vivo Evaluation as Anticancer Agents

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Authors

RDRahul DubeySGShankar GuptaRSRajveer Singh

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Overview

This research examines triazole-pyrimidine hybrids as anticancer agents, highlighting their effectiveness against EGFR in lung cancer models.

Key Points

  • RDg exhibited a strong IC50 of 15.70 µM against the A549 lung cancer cell line, demonstrating significant anticancer potential.
  • In vivo studies with RDg in the EAC mouse model achieved a remarkable 52% reduction in tumor volume, outperforming erlotinib.
  • In silico analyses revealed RDg's effective binding to EGFR, showcasing significant molecular stability and strong interaction potentials.
  • The study indicates RDg's potential as a lead compound for developing new EGFR inhibitors in lung cancer therapies.

Cite This Study

Dubey et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478cb6ehttps://doi.org/10.1002/ddr.70154
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Discovery of Potent and Selective Pyrrolo[2,3-<i>d</i>]pyrimidine Derivatives as Fourth-Generation EGFR Inhibitors Targeting Triple Mutations2025
  2. 2Design, Synthesis, In Silico Evaluation, and Biological Assessment of Novel Pyrido[2,3‐d]Pyrimidine Derivatives as Potential Anticancer Agents2025
  3. 3Advancing EGFR-targeted anticancer strategies: the potential of thiazole, pyrazole, and thiazole–pyrazole hybrids2025
  4. 4Synthesis and in-vitro anti-EGFR screening of new 1,2,3-triazole-benzimidazole hybrids and insilico studies2025
  5. 5Molecular Docking Study of Five Novel 1,2,3-Triazole Linked Metronidazole Derivatives as Cytotoxic Agents2024