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September 10, 2025Orthopaedic Proceedings

Triply Periodic Minimal Surface Architecture Improves Bone Growth in 3d-Printed Polycaprolactone Scaffolds

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Authors

HOHisham OmarPLPaulina Bargallo Gonzalez LugoRBRachel Bonfini

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Overview

3D-printed polycaprolactone scaffolds enhance bone growth in vitro, suggesting optimal designs for repair.

Key Points

  • Gyroid PCL scaffolds doubled bone formation compared to honeycomb scaffolds at 4 weeks, indicating design superiority.
  • Micro-CT analysis revealed gyroid samples achieved 58.5 mm³ bone volume, significantly more than honeycomb samples.
  • Alamar Blue assays demonstrated high cell viability across all constructs during a 4-week incubation period.
  • Despite enhanced bone growth, honeycomb scaffolds showed greater mechanical strength, highlighting a design tradeoff.

Cite This Study

Omar et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478cb46https://doi.org/10.1302/1358-992x.2025.6.017
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Also Consider

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