Remote Ischemic Conditioning Attenuates Apoptosis, the Inflammatory Response, and Reperfusion Injury in Ischemic-Stroke Model Rats via the ELA-Apelin-APJ System
This experimental investigation shows RIC alleviates apoptosis and inflammation in stroke rats, indicating its therapeutic potential.
Key Points
RIC significantly decreased cerebral infarct volume and neuronal damage in ischemic stroke models.
The RIC-treated group had notably lower levels of caspase-3, TNF-α, IL-1β, p-STAT3, HIF-1α, and ATF4 compared to MCAO controls.
Increased Elabela and apelin levels in the RIC group correlated positively with STAT3, while negatively with caspase-3, suggesting a protective mechanism.
This study highlights the potential of RIC in modulating the ELA-apelin-APJ system for treating ischemic stroke.