Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
September 10, 2025

Vitamin D restores redox balance and modulates irisin and spexin expression in a rat model of streptozotocin-induced diabetic nephropathy

View Full Paper
Ask AI
Bookmark
Share

Authors

MUMustafa UlaşEÖEbru Bardaş ÖzkanMÇMustafa Nusret Çiçekli

Discussion

Loading...

Member takes

Overview

Animal study shows vitamin D supplementation enhances irisin and spexin in diabetic nephropathy, suggesting therapeutic potential.

Key Points

  • Vitamin D supplementation reversed pathological changes in diabetic nephropathy, improving renal function and peptide levels.
  • Significant elevations in serum creatinine, BUN, LDH, and TOS were observed in diabetic nephropathy alongside reduced irisin and spexin.
  • Assessment included renal function markers, oxidative stress parameters, and histopathological evaluations over an 8-week period.
  • Findings suggest vitamin D promotes redox stabilization and upregulation of irisin and spexin as potential therapeutic targets.

Cite This Study

Ulaş et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c83ahttps://doi.org/10.21203/rs.3.rs-7373046/v1
View Full Paper
Ask AI
Bookmark
Share