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September 10, 2025Open Access

Metformin-induced longevity is associated with retrotransposon dynamics in yest chronological aging

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Authors

JMJimena Meneses-PlascenciaEMEricka Moreno‐MéndezDADiana Ascencio

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Overview

This study finds metformin enhances lifespan in yeast, suggesting chromatin regulation and retrotransposon activity are key components.

Key Points

  • Metformin promotes longevity in saccharomyces cerevisiae by influencing chromatin regulation and retrotransposon expression.
  • Transcriptome profiling showed metformin induced retrotransposon activity, which is linked to chromatin-modifying factors.
  • A combination of genetic screening and proteomic analysis was performed to uncover cellular mechanisms of metformin's effects on yeast.
  • The results highlight the complex relationship between gene expression and retrotransposition, pointing to novel anti-aging mechanisms.

Cite This Study

Meneses-Plascencia et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c70chttps://doi.org/10.1101/2025.09.07.674784
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