September 10, 2025NutrientsOpen Access

Perspective: Vitamin D Deficiency Relationship to Initiation of Diseases

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Perspective examines the impact of vitamin D deficiency on disease initiation and indicates the need for effective public health strategies.

Vitamin D deficiency can compromise calcium homeostasis and contribute to disease onset in individuals.
Clinical trials assessing vitamin D supplementation for disease treatment have yielded largely inconclusive results.
The protective functions of locally produced 1,25(OH)2D in nonrenal cells are impaired during vitamin D deficiency.
Maintaining adequate vitamin D status year-round is crucial for preventing disease initiation and progression.

David R. Fraser (2025) studied this question.

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Perspective examines the impact of vitamin D deficiency on disease initiation and indicates the need for effective public health strategies.