September 10, 2025MetabolitesOpen Access

Multiparametric Evaluation of Drug-Induced Acute Kidney Injury Using Preclinical 7T Magnetic Resonance Imaging in Rat Models

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Significant changes in relaxation times were observed in renal cortex following gentamicin treatment.
Blood tests demonstrated marked increases in sodium, creatinine, and urea nitrogen in disease model rats.
T1 and T2 maps showed distinct variations between control and gentamicin-treated groups, indicating renal injury.
HE staining confirmed renal tissue damage, underscoring the utility of MRI in AKI assessment.

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Multiparametric analysis shows changes in renal function in rats due to gentamicin, indicating severe AKI.

Natsuyama et al. (2025) studied this question.

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