September 10, 2025Microbiology SpectrumOpen Access

Proviral functions of HMGB1 in HAdV-C5 replication compartments

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HMGB1 is essential for efficient viral gene expression during HAdV-C5 replication, demonstrating its proviral function.
Quantitative proteomics identified HMGB1 in replication compartments, highlighting its role in modulating viral replication.
The study employs click-chemistry and proximity ligation assays to investigate HMGB1's location and interactions during adenovirus infection.
Despite decreased levels in late infection stages, HMGB1 continues to support viral replication by interacting with essential viral proteins.

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Implication

Quantitative proteomics reveals HMGB1's crucial role in viral replication within adenovirus compartments, suggesting implications for virus-host interactions.

Cite This Study

Hidalgo et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c4a1 https://doi.org/10.1128/spectrum.01958-25

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Implication

Quantitative proteomics reveals HMGB1's crucial role in viral replication within adenovirus compartments, suggesting implications for virus-host interactions.

Proviral functions of HMGB1 in HAdV-C5 replication compartments

Key Points

Discussion

Implication

Cite This Study

Proviral functions of HMGB1 in HAdV-C5 replication compartments

Key Points

Discussion

Implication

Cite This Study