Limiting viral replication in hematopoietic cells delays Rift Valley fever virus disease progression in C57BL/6 mice
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Key Points
Limiting viral replication in hematopoietic cells delays disease progression of RVFV in mice.
C57BL/6 mice showed delayed viral replication with RVFVmiR-142 compared to control RVFVmiR-MM.
Increased type I IFN response correlated with restricted replication in popliteal lymph nodes.
Findings indicate hematopoietic cells contribute to viral amplification and spread in RVFV pathogenesis.
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Implication
Observational analysis reveals reduced disease severity in C57BL/6 mice infected with miRNA-targeted virus, suggesting hematopoietic cells play a key role.