September 10, 2025Journal of Intensive Care Medicine

Impact of Metabolically Healthy and Unhealthy Obesity on Outcomes of Sepsis Complicated by Septic Shock in Elderly Patients

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Authors

GCGiorgi ChilingarashviliNazareth Hospital DPDiksha Sanjana Pasnoor SBShreya BajjuriAcademy of Medical Sciences

Discussion

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Implication

Retrospective analysis reveals that both metabolically healthy obesity and unhealthy obesity impact sepsis outcomes in elderly patients, suggesting the need for improved risk stratification.

Key Points

Higher respiratory failure rates are associated with both metabolically healthy obesity and unhealthy obesity in elderly patients.
Among 268,050 obese patients, 1.4% were metabolically healthy while 14.1% were metabolically unhealthy, indicating a significant prevalence in the population.
Adjusted odds ratios found that both obesity phenotypes increased the risk of respiratory failure and mechanical ventilation compared to non-obese patients.
The study highlights how identifying obesity phenotypes can improve sepsis risk stratification and inform targeted management strategies.

Cite This Study

Chilingarashvili et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478c130 https://doi.org/10.1177/08850666251372543

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Implication

Retrospective analysis reveals that both metabolically healthy obesity and unhealthy obesity impact sepsis outcomes in elderly patients, suggesting the need for improved risk stratification.