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September 10, 2025American Journal of Nephrology

Plasma IL-22 predicts progression of early diabetic kidney disease

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Authors

BFBeatriz Fernández‐FernándezTHTakehiro HasegawaYSYuko Saruta

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Overview

Prospective study identifies plasma IL-22 and TNF-α as indicators of CKD progression in diabetic kidney disease patients.

Key Points

  • Progression of CKD is significantly predicted by plasma IL-22 and TNF-α levels in early diabetic kidney disease patients.
  • After about 7.27 years of follow-up, 32.5% of patients with preserved GFR progressed to advanced CKD stages.
  • Cytokine dysregulation, indicated by high plasma IL-22, may occur before measurable decline in kidney function.
  • Cluster analysis links elevated cytokine levels with poor GFR outcomes, emphasizing the need for early risk assessment.

Cite This Study

Fernández‐Fernández et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478c03fhttps://doi.org/10.1159/000547738
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