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September 10, 2025VirulenceOpen Access

Manipulation of macrophage signaling by Leishmania virulence factors

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Authors

DGDhiraj GurjarNational Centre for Cell ScienceNBNeelam BodhaleNational Centre for Cell ScienceDSDivanshu ShuklaParker Institute for Cancer Immunotherapy

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Implication

This review reveals how leishmania virulence factors alter macrophage signaling and suggests new interaction frameworks.

Key Points

  • Leishmania virulence factors alter macrophage signaling and influence disease outcomes.
  • Notably, eEF-1α and LmjF_36_3850 modulate protein kinase C activation affecting T cell behavior.
  • The exploration of phosphoinositide signaling highlights new insights into host-parasite interactions.
  • 170 PX-domain-containing proteins are involved in critical signaling and membrane trafficking processes.

Cite This Study

Gurjar et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478c018https://doi.org/10.1080/21505594.2025.2549802
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