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September 10, 2025American Journal of Therapeutics

Polypharmacy Intervention Studies in Older Adults: Challenges in Proving Benefits in Hard Clinical Outcomes

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Authors

LILaura Mihaela IsopTransylvania University of BrașovANAndrea Elena NeculauTransylvania University of BrașovCKCornelis KramersRadboud University Nijmegen

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Implication

Review evaluates polypharmacy interventions' impacts on clinical outcomes in older adults, suggesting enhanced collaboration may improve results.

Key Points

  • Polypharmacy interventions show limited impact on clinical outcomes like mortality and hospitalization rates.
  • Data from systematic reviews and trials indicate the need for structured implementation in managing polypharmacy.
  • High-intensity interventions involving multidisciplinary teams have potential in reducing adverse drug reactions.
  • Future approaches should emphasize patient-centered strategies and include technology for better management.

Cite This Study

Isop et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478be64https://doi.org/10.1097/mjt.0000000000002010
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