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September 10, 2025Annals of the American Thoracic Society

Neutrophil-to-Lymphocyte Ratio (NLR) as a Biomarker in Clinically Stable Chronic Obstructive Pulmonary Disease: SPIROMICS cohort

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Authors

DHDANIEL HOESTEREYHDHong DangUniversity of North Carolina at Chapel HillDMDaniela MarkovicLos Angeles County Department of Health Services

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Implication

Observational analysis finds elevated NLR linked to worse COPD features and outcomes in patients, indicating a potential prognostic role.

Key Points

  • Higher neutrophil-to-lymphocyte ratios are linked to more severe clinical features of COPD, increasing risks.
  • The highest NLR quartile (>3.11) correlates with a 51% increase in exacerbation risk and a 41% increase in mortality risk over one year.
  • Observational analysis assessed the relationship between NLR and various clinical outcomes across a large cohort of COPD patients.
  • The impact of smoking on NLR varies with airflow limitation severity, suggesting tailored approaches in COPD management may be needed.

Cite This Study

HOESTEREY et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478bc61https://doi.org/10.1513/annalsats.202412-1265oc
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