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September 10, 2025Proceedings of the National Academy of SciencesOpen Access

Single-cell transcriptome combined with genetic tracing reveals a roadmap of fibrosis formation during proliferative vitreoretinopathy

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Authors

MLMengyu LiaoZYZ. YeYZYumeng Zhao

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Implication

Study reveals single-cell insights on ocular fibrosis progression in proliferative vitreoretinopathy, highlighting TSP-1's role.

Key Points

  • Identified cellular origins of fibroblasts in proliferative vitreoretinopathy, emphasizing retinal pigment epithelial contributions.
  • Single-cell transcriptomic analysis showed RPE cells transitioning through multiple stages during PVR formation, indicating significant plasticity.
  • Cell communication network analysis pinpointed TSP-1 as a crucial gene in RPE cell fate transitions during ocular wound healing.
  • Therapeutic targeting of TSP-1 markedly reduced the progression of proliferative vitreoretinopathy, suggesting a potential treatment avenue.

Cite This Study

Liao et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478bc17https://doi.org/10.1073/pnas.2424487122
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