Outcomes of hematopoietic stem cell transplantation using melphalan-based conditioning in children with acquired aplastic anemia

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Observational analysis shows successful graft function in children with acquired aplastic anemia, suggesting melphalan enhances outcomes.

All patients achieved good graft function without severe complications, indicating melphalan's potential benefits.
Ninety-five percent of patients achieved full donor cell chimerism, with significant implications for treatment success.
Retrospective analysis examined 21 children undergoing HSCT with melphalan-based conditioning as first or repeat procedures.
These findings suggest a promising approach to reduce graft rejection risk and improve outcomes in pediatric patients.

Скоробогатова et al. (2025) studied this question.

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