September 10, 2025Blood AdvancesOpen Access

The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility.

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Analysis reveals ELDR regulates DNA replication and chromatin accessibility in MLL-r AML cells, suggesting therapeutic implications.

Forced expression of ELDR led to enhanced growth inhibition in AML cells treated with LSD1i/ATRA, improving leukemia-free survival.
AML cells with increased ELDR showed defects in DNA replication fork progress and reduced chromatin accessibility at centromeres.
ELDR interacts with proteins like PCNA and MCM5, implicating its role in both DNA replication and centromere function.
Future strategies may leverage ELDR delivery alongside existing treatments to improve outcomes in MLL-r AML.

Arman et al. (2025) studied this question.

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