September 10, 2025Open Access

Effect of morphine dependence and withdrawal on operant social interaction in male and female rats

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Opioid dependence significantly decreased operant social interaction in both male and female rats.
Social self-administration was assessed in 66 rats, with interaction rates lower during morphine dependence.
Preclinical assessments involved varying morphine doses and pharmacological agents without reversing social interaction deficits.
Findings suggest that the impact of opioid dependence on social behavior is independent of kappa opioid, serotonin, or dopamine signaling.

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Experimentally induced opioid dependence reduced operant social interaction in rats, indicating the complex effects of withdrawal.

Pilz et al. (2025) studied this question.

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