Treatment Strategies of Esophageal Cancer With Concurrent Cervical Node Metastasis: A Dutch Nationwide Population-Based Cohort Study

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Neoadjuvant therapy followed by surgery improves overall survival compared to definitive chemo-radiotherapy.
Patients receiving neoadjuvant therapy had a median overall survival of 24 months versus 18 months for dCRT.
Cox regression analysis indicated a 44% lower risk of death for patients undergoing neoadjuvant therapy.
The study underscores the need for more prospective studies to confirm the viability of surgical intervention.

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Population-based cohort study highlights neoadjuvant therapy's survival advantage in esophageal cancer patients with cervical lymph node metastasis.

Sanders et al. (2025) studied this question.

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Population-based cohort study highlights neoadjuvant therapy's survival advantage in esophageal cancer patients with cervical lymph node metastasis.