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September 10, 2025Diseases of the Esophagus

Neoadjuvant Chemoimmunotherapy Versus Chemotherapy Plus Esophagectomy for Esophageal Squamous Cell Carcinoma: Primary Result of a Randomized Clinical Trial

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BLBin Li

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Overview

Randomized clinical trial compares event-free survival in patients receiving neo-adjuvant chemoimmunotherapy versus chemotherapy, suggesting efficacy of immunotherapy.

Key Points

  • Immunochemotherapy leads to higher rates of pathological complete response in esophageal squamous cell carcinoma.
  • Out of patients treated, 11.7% achieved complete response with immunotherapy, compared to 1.6% with chemotherapy.
  • The trial involved 177 patients, with safety profiles for both treatments considered acceptable.
  • Long-term follow-up is needed to fully assess the survival benefits of neoadjuvant immunotherapy.

Cite This Study

Bin Li (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478b8e8https://doi.org/10.1093/dote/doaf061.067
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Editorial: The role of adjuvant and neoadjuvant therapy in resectable esophageal cancer2025
  2. 2150. NEOADJUVANT CHEMOIMMUNOTHERAPY WITH ADAPTIVE RADIOTHERAPY FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA: STUDY PROTOCOL FOR A PROSPECTIVE MULTICENTER PHASE II TRIAL2025
  3. 3Adjuvant immunotherapy in esophageal squamous cell carcinoma after radiotherapy: retrospective multicentric survival analysis2025
  4. 4023. CHEMOTHERAPY COMBINED WITH IMMUNOTHERAPY FOLLOWED BY SALVAGE LYMPHADENECTOMY FOR RECURRENCE IN CERVICAL LYMPH NODES AFTER ESOPHAGECTOMY: A SINGLE-CENTER PROSPECTIVE STUDY2025
  5. 5236. SAFETY AND EFFICACY OF CAMRELIZUMAB COMBINED WITH RADIOTHERAPY AS NEOADJUVANT THERAPY FOR LOCALLY ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA2025