The Therapeutic Effects of Neo-Adjuvant Therapy on Lymph Nodes Metastasis for Locally Advanced Esophageal Cancer

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Discussion

Multicenter randomized trial evaluates lymph node metastasis and overall survival in esophageal cancer patients, highlighting therapy effectiveness.

Chemoradiotherapy shows superior pCR rates at 35.7% compared to 3.8% for chemotherapy.
Three-year survival rates are similar between groups, at 64.1% and 54.9%, indicating comparable outcomes.
Higher harvested lymph node numbers correlate with improved overall survival in patients with positive nodes.
Positive lymph node presence indicates poorer survival outcomes in both treatment cohorts.

Gong et al. (2025) studied this question.

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Multicenter randomized trial evaluates lymph node metastasis and overall survival in esophageal cancer patients, highlighting therapy effectiveness.