Large Cell Neuroendocrine Carcinoma of the Oesophagus: A Rare Entity. Systematic Review of the Literature in Regards to Its Management

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Systematic review identifies treatment strategies and survival rates for rare oesophageal cancer, suggesting oesophagectomy may improve outcomes.

Oesophagectomy appears to improve overall survival rates for patients with large cell neuroendocrine carcinoma of the oesophagus, indicating its potential as a key treatment option.
Among the 31 patients undergoing oesophagectomy, overall survival ranged from 10.5 to 96 months, suggesting significant variability in patient outcomes based on disease stage.
The systematic literature review evaluated 3373 abstracts to identify 35 relevant papers, underscoring the limited evidence available for managing this rare cancer.
Further research and broader reporting are essential to distinguish treatment strategies between large cell neuroendocrine carcinoma and small cell neuroendocrine carcinoma for better understanding.

Hopping et al. (2025) studied this question.

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Systematic review identifies treatment strategies and survival rates for rare oesophageal cancer, suggesting oesophagectomy may improve outcomes.