Inter-Institutional Survival Heterogeneity Between Surgery and Chemoradiotherapy for Clinical Stage I Esophageal Cancer: Exploratory Analysis of Jcog0502

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No significant difference in overall survival (87% vs. 93%) between high- and low-enrollment centers for surgery group.
The progression-free survival was 81% in high centers compared to 93% in low centers, indicating a trend worth exploring.
High-enrollment centers showed lower rates of adverse events compared to low centers, particularly in the chemoradiotherapy group.
Institutional variations potentially influence treatment selection and patient outcomes in stage I esophageal cancer.

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Exploratory analysis finds no significant survival differences in treatment for stage I esophageal cancer, revealing institutional variability.

Shiraishi et al. (2025) studied this question.

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Exploratory analysis finds no significant survival differences in treatment for stage I esophageal cancer, revealing institutional variability.