September 10, 2025Open Access

Single-cell transcriptomics and machine learning reveal RNF144B and C5AR1 as immune-related biomarkers and therapeutic targets in myocardial infarction

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Integration of transcriptomic data and machine learning reveals RNF144B and C5AR1 as key immune biomarkers, suggesting novel therapeutic approaches.

A robust 13-gene signature was established, pinpointing RNF144B and C5AR1 as potential biomarkers for myocardial infarction.
Correlation analysis indicated a significant relationship of RNF144B and C5AR1 with immunological roles and classical MI marker genes.
Gene Set Enrichment Analysis revealed RNF144B enrichment in neutrophil degranulation, suggesting a role in inflammation.
Molecular docking identified CCX168 as a promising candidate to target RNF144B and C5AR1, highlighting potential therapeutic strategies.

Hu et al. (2025) studied this question.

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Integration of transcriptomic data and machine learning reveals RNF144B and C5AR1 as key immune biomarkers, suggesting novel therapeutic approaches.