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September 10, 2025

COX-2 Mediates Immune Evasion and Decreases Chemosensitivity in Breast Cancer Through Activation of the JAK2/STAT3 Signalling Pathway.

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Authors

GLGuohua LiuPLPeng LiuKLKai Liang

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Overview

Experimental findings show COX-2 activation decreases chemosensitivity and promotes immune evasion, suggesting critical therapy targets.

Key Points

  • Downregulation of COX-2 enhances apoptosis and responsiveness to chemotherapy in breast cancer cells.
  • Tumour cells with overexpressed COX-2 exhibit increased resistance to chemotherapy and immune evasion.
  • Inhibition of the JAK2/STAT3 pathway reverses the effects of COX-2 overexpression on breast cancer cell survival.
  • COX-2 activation of the JAK2/STAT3 pathway is strongly associated with diminished chemosensitivity in breast cancer.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478af14https://doi.org/10.1111/imm.70031
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